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Fecal Transplants Promising for Treating Intestinal Issues, Still Fecal Transplants

Antibiotics, while being one of the greatest advances in medical history, have their downsides. Sometimes, they can do some collateral damage and destroy cultures of bacteria that rightfully belong in the human body, nice cultures of nice bacteria. When these get killed, problems start. One of the more common instances of this has to do with intestinal bacteria. When the intestinal bacteria landscape gets screwed up, sometimes the only way to right the situation is to reintroduce a culture of healthy bacteria to the area. How do you do that? A fecal transplant.

Basically, a fecal transplant is performed by taking stool from a healthy person, diluting it, and — there’s really not a better word for this — “squirting” it into the recipient’s colon. This process has been performed on a number of patients on a number of different occasions and worked, so there is a decent catalog of anecdotal evidence that the procedure can alleviate symptoms like chronic diarrhea almost immediately. The main problem that’s preventing the procedure from gaining more traction is largely a technical one. It turns out that “feces” don’t fit any of the FDA’s established classifications, so it’s very difficult to figure out how to go about clinical testing or widespread adoption.

What that means for the people who might benefit from this is that many doctors don’t do the procedure, and no insurance companies will cover it. There are, however, doctors who are strong supporters of the fecal transplant and will perform one, or try and help the patient find a way to do it themselves. Michael Sliverman of the University of Toronto, for example, suggested that patients could relatively easily perform a transplant themselves by using an enema kit.

Even when the procedure is performed by a doctor, the patient plays a pretty big part. One of the most important steps for the patient is simply getting over the squick factor. Of course, these individuals have often been living with digestive problems for years, so they might be more willing to receive a stool transplant from another person than, say, you or me.

If they can get over that hurdle, they are also generally expected to find their own donor, and they usually want to. Fortunately, it doesn’t take much for a stool transplant to be compatable, and it’s not like the donor will be giving up anything particularly valuable like an organ. Most patients who undergo this procedure turn to a child, sibling, parent or spouse. “For me, it’s aesthetic,” says Christina SurawiczUniversity of Washington professor of medicine. She’s done the procedure over 20 times, and published an account of the first 19.

“There’s something very intimate about putting someone else’s stool in your colon, and you are already intimate with a spouse.”

Unfortunately, while anecdotal evidence is heartening, it’s not clinical evidence, and clinical evidence is what the FDA really wants. Hopefully, the feces classification issue is something that can eventually be cleared up so that it can happen. Fortunately enough, for the afflicted who can make their peace with a feces transplant and decide to try it, the cost, stakes, and expertise needed are low enough that they can probably find someone to do it, or find a way to do it themselves and attempt to allievate their chronic symptoms. Whatever the future of fecal transplants may be, I can tell you this much: They will always be pretty gross.

(Scientific American via BoingBoing)

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